What causes high creatinine levels in body?

Progressive loss of kidney function over time can lead to elevated creatinine levels due to the kidneys' decreased ability to filter waste.

Sudden damage to the kidneys from various causes such as severe dehydration, shock, or toxins can result in a rapid increase in creatinine levels.

High blood sugar levels can damage blood vessels in the kidneys, impairing their function and leading to elevated creatinine.

Hypertension can cause damage to the kidney's blood vessels, reducing their filtering ability and increasing creatinine levels.

Certain drugs (like NSAIDs, some antibiotics) and toxins can directly harm the kidneys, leading to increased creatinine.

Conditions such as sepsis can cause a rapid decline in kidney function, resulting in elevated creatinine levels.

Diseases causing significant muscle breakdown (like rhabdomyolysis) release large amounts of creatinine into the bloodstream, overwhelming the kidneys.

Blockages in the urinary tract (such as kidney stones or tumors) can impair urine flow, leading to kidney damage and high creatinine levels.